balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hv1a) receptor antagonist, with kis of 1 and 39 nm for human (hv1a) and mouse (mv1a) receptors. it is used for the research of autism.
bamb-4 is a highly membrane-permeable inhibitor of inositol-1,4,5-trisphosphate-3-kinase a (itpka). it acts by suppressing the metastasis-promoting effect of itpka in lung tumor cells(with ic50 of 37 μm in adp-glo assay).
bay-2402234 is an inhibitor of dihydroorotate dehydrogenase (dhodh) for the treatment of myeloid malignancies.bay 2402234 is a selective low-nanomolar inhibitor of human dhodh enzymatic activity.
levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active l-isomer of ofloxacin with antibacterial activity. levofloxacin diffuses through the bacterial cell wall and acts by inhibiting dna gyrase (bacterial topois
bay1082439 is highly effective in inhibiting pten-null prostate cancer growth[1][2] and it is an orally bioavailable, selective pi3kα/β/δ inhibitor. bay1082439 also inhibits mutated forms of pik3ca.
axitinib is an orally bioavailable tyrosine kinase inhibitor with ic50s of 0.1, 0.2, 0.1-0.3, 1.7, 1.6 nm for vegfr1, vegfr2, vegfr3, c-kit, and pdgfrβ, respectively.
bi-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on th2 cells (dp2/crth2). with ic50 values of 4.5 nm and 3.7 nm for pgd2 binding to crth2 in hcrth2 and mcrth2 transfected cells, respectively. bi-671800
biotin-dadoo is a biotinylation reagent,which can be used to synthesize a biotin-estradiol conjugate (i.e., biotin-dadoo-estradiol) to develop a direct, broad range enzyme immunoassay to measure plasma estradiol concentrations.
biotin hydrazide is a carbonyl-reactive biotinylation reagent, which is a carbonyl probe. biotin hydrazide is a great choice for labeling mouse monoclonal antibodies, lectins, sugars, unpaired cytosine residues in nucleic acids, and glycoprotiens.
epalrestat, an aldose reductase inhibitor, is well tolerated in long-term therapy. it can effectually ameliorate the associated symptoms of diabetic neuropathy and delay the progression of the disease, particularly in patients with limited microangiopathy
biotin-peg3-acid is a biotin-labeled, peg-based protac linker that can be used in the synthesis of protacs.biotin-peg3-acid is a heterobiofunctional biotin peg derivative containing a carboxylic acid group. the hydrophilic peg spacer arm imparts water sol
captopril is a potent and specific inhibitor of peptidyl-dipeptidase a. it blocks the conversion of angiotensin i to angiotensin ii, a vasoconstrictor and important regulator of arterial blood pressure.
toremifene citrate is a selective estrogen receptor modulator (serm). it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on the mammary and uterine tissue.
motixafortide is an antagonist of cxcr4 with ic50 of ~1 nm. it induces the apoptosis of aml blasts by down-regulating erk, bcl-2, mcl-1 and cyclin-d1 via altered mir-15a/16-1 expression.
acemetacin is a carboxymethyl ester of indometacin. it is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin. in clinical trials, acemetaci
lornoxicam (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (nsaid) of the oxicam class with analgesic, anti-inflammatory, and antipyretic properties. lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin bi
bms-986158 is a potent bet inhibitor with ic50s of 6.6 and 5 nm in nci-h211 small cell lung cancer (sclc) cells and mda-mb231 triple negative breast cancer (tnbc) cells, respectively.
bms-986165 inhibits il-12/23 and type i ifn pathways[1][2]. bms-986165 is a highly selective, orally bioavailable allosteric tyk2 inhibitor for the treatment of autoimmune diseases. which selectively binds to tyk2 pseudokinase (jh2) domain (ic50=1.0 nm) a
bmx-in-1 is a selective inhibitor of bone marrow tyrosine kinase on chromosome x (bmx, ic50 = 8 nm) and the related bruton’s tyrosine kinase (btk, ic50 = 10.4 nm), but bmx-in-1 is more than 47-656 fold less potent against blk, jak3, egfr, itk, or tec acti
fexofenadine hydrochloride is a carboxylated metabolic derivative of terfenadine and long-lasting selective histamine h1 receptor antagonist, with antihistaminic activity.
duloxetine hydrochloride is a thiophene derivative and selective neurotransmitter uptake inhibitor for serotonin and noradrenaline (snri). it is an antidepressive agent and anxiolytic and is also used for the treatment of pain in patients with diabetes me
trospium is an antispasmodic and anticholinergic agent used to treat urinary incontinence and overactive bladder syndrome. trospium has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.
trilostane is a synthetic derivative of androstane with adrenocortical suppressive properties. trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex.